Cefspan may be available in the countries listed below.
Ingredient matches for Cefspan
Cefixime is reported as an ingredient of Cefspan in the following countries:
- Indonesia
- Japan
- Taiwan
- Vietnam
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Cefspan may be available in the countries listed below.
Cefixime is reported as an ingredient of Cefspan in the following countries:
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AZ may be available in the countries listed below.
Azelastine is reported as an ingredient of AZ in the following countries:
Azithromycin dihydrate (a derivative of Azithromycin) is reported as an ingredient of AZ in the following countries:
Sodium Bicarbonate is reported as an ingredient of AZ in the following countries:
Sodium Gualenate is reported as an ingredient of AZ in the following countries:
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Amoxicillina + Acido clavulanico Jet may be available in the countries listed below.
Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Amoxicillina + Acido clavulanico Jet in the following countries:
Clavulanic Acid potassium (a derivative of Clavulanic Acid) is reported as an ingredient of Amoxicillina + Acido clavulanico Jet in the following countries:
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Horizant is a brand name of gabapentin, approved by the FDA in the following formulation(s):
No. There is currently no therapeutically equivalent version of Horizant available.
Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Horizant. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.
See also: About generic drugs.
Patents are granted by the U.S. Patent and Trademark Office at any time during a drug's development and may include a wide range of claims.
Exclusivity is exclusive marketing rights granted by the FDA upon approval of a drug and can run concurrently with a patent or not. Exclusivity is a statutory provision and is granted to an NDA applicant if statutory requirements are met.
Doxylin may be available in the countries listed below.
Doxycycline hyclate (a derivative of Doxycycline) is reported as an ingredient of Doxylin in the following countries:
Doxycycline hydrochloride (a derivative of Doxycycline) is reported as an ingredient of Doxylin in the following countries:
Doxycycline monohydrate (a derivative of Doxycycline) is reported as an ingredient of Doxylin in the following countries:
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Azitromicina Dupomar may be available in the countries listed below.
Azithromycin is reported as an ingredient of Azitromicina Dupomar in the following countries:
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Blu-Gard may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Dodecylbenzene Sulfonic Acid is reported as an ingredient of Blu-Gard in the following countries:
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Herten Plus may be available in the countries listed below.
Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of Herten Plus in the following countries:
Hydrochlorothiazide is reported as an ingredient of Herten Plus in the following countries:
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Viscomucil may be available in the countries listed below.
Ambroxol hydrochloride (a derivative of Ambroxol) is reported as an ingredient of Viscomucil in the following countries:
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In the US, Cedax (ceftibuten systemic) is a member of the drug class third generation cephalosporins and is used to treat Bladder Infection, Bronchitis, Otitis Media, Pneumonia, Sinusitis, Strep Throat and Tonsillitis/Pharyngitis.
US matches:
Ceftibuten is reported as an ingredient of Cedax in the following countries:
Ceftibuten dihydrate (a derivative of Ceftibuten) is reported as an ingredient of Cedax in the following countries:
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Nalorfina may be available in the countries listed below.
Nalorfina (DCIT) is also known as Nalorphine (Rec.INN)
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Glossary
| DCIT | Denominazione Comune Italiana |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
Remylin may be available in the countries listed below.
Mecobalamin is reported as an ingredient of Remylin in the following countries:
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Fungares may be available in the countries listed below.
Miconazole nitrate (a derivative of Miconazole) is reported as an ingredient of Fungares in the following countries:
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Generic Name: brompheniramine (brome feh NEER a meen)
Brand Names: BroveX, BroveX CT, Dimetane, Dimetane Extentab, Dimetapp Allergy, Dimetapp Allergy Liquigel, Lodrane 12 Hour
Brompheniramine is an antihistamine. Brompheniramine blocks the effects of the naturally occurring chemical histamine in the body.
Brompheniramine is used to sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold.
Brompheniramine may also be used for purposes other than those listed in this medication guide.
Before taking brompheniramine, talk to your doctor if you have
glaucoma or increased pressure in the eye;
a stomach ulcer;
an enlarged prostate, bladder problems or difficulty urinating;
an overactive thyroid (hyperthyroidism);
hypertension or any type of heart problems; or
asthma.
You may not be able to take brompheniramine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
Take brompheniramine exactly as directed on the package or as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
Brompheniramine can be taken with or without food.
To ensure that you get a correct dose, measure the liquid form of brompheniramine with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.
Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.
Symptoms of a brompheniramine overdose may include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.
Do not take other over-the-counter cough, cold, allergy, diet, pain, or sleep medications while taking brompheniramine without first talking to your pharmacist or doctor. Other medications may also contain brompheniramine or other similar drugs, and you may accidentally take too much of these medicines.
Brompheniramine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if brompheniramine is taken with any of these medications.
Other, less serious side effects may be more likely to occur. Continue to take brompheniramine and talk to your doctor if you experience
sleepiness, fatigue, or dizziness;
headache;
dry mouth; or
difficulty urinating or an enlarged prostate.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Do not take other over-the-counter cough, cold, allergy, diet, pain, or sleep medications while taking brompheniramine without first talking to your pharmacist or doctor. Other medications may also contain brompheniramine or other similar drugs, and you may accidentally take too much of these medicines.
Brompheniramine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if brompheniramine is taken with any of these medications.
Drugs other than those listed here may also interact with brompheniramine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.
See also: Dimetapp Allergy Liquigel side effects (in more detail)
Ceftazidime Kabi may be available in the countries listed below.
Ceftazidime pentahydrate (a derivative of Ceftazidime) is reported as an ingredient of Ceftazidime Kabi in the following countries:
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In the US, Xolair (omalizumab systemic) is a member of the drug class other immunosuppressants and is used to treat Asthma, Maintenance.
US matches:
UK matches:
Omalizumab is reported as an ingredient of Xolair in the following countries:
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Glossary
| SPC | Summary of Product Characteristics (UK) |
Generic Name: valdecoxib (Oral route)
val-de-KOX-ib
Serious skin reactions (eg, toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme) have been reported in patients receiving valdecoxib, some resulting in death. Patients appear to be at higher risk for these events during the first 2 weeks of treatment, but these may occur at any time. Valdecoxib should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity .
In the U.S.
Available Dosage Forms:
Therapeutic Class: Analgesic
Pharmacologic Class: Cyclooxygenase-2 Inhibitor
Valdecoxib is a non-steroidal anti-inflammatory drug. Nonsteroidal anti-inflammatory drugs (also called NSAIDs) are used to relieve some symptoms caused by arthritis (rheumatism), such as inflammation, swelling, stiffness, and joint pain. However, this medicine does not cure arthritis and will help you only as long as you continue to take it. It may also be used to treat pain associated with menstrual periods.
This medicine was available only with your doctor's prescription.
Valdecoxib was voluntarily withdrawn from the U.S. market on April 7, 2005 due to safety concerns of increased risk of serious heart problems and skin reactions .
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of valdecoxib in children with use in other age groups.
This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | C | Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. |
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
The following section is for information only, since the drug is no longer available.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
If you will be taking this medicine for a long time, it is very important that your doctor check you at regular visits.
Stomach problems may be more likely to occur if you drink alcoholic beverages while being treated with this medicine. Therefore, do not regularly drink alcoholic beverages while taking this medicine, unless otherwise directed by your doctor.
Serious side effects can occur during treatment with this medicine. Sometimes serious side effects can occur without any warning. However, possible warning signs often occur, including swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, sticky stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; and/or skin rash. Stop taking this medicine and check with your doctor immediately if you notice any of these warning signs.
Serious skin reactions can occur during treatment with valdecoxib. Check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, loosening of skin, chills, cough, diarrhea, fever, itching, joint or muscle pain, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, white spots in mouth or on lips, or unusual tiredness or weakness.
Check with your doctor immediately if fever, drowsiness, itching of the skin, tiredness, nausea, or stomach pain occurs; these effects may be the first signs of liver toxicity.
Valdecoxib may cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur often in patients who are allergic to aspirin, other nonsteroidal anti-inflammatory drugs, or sulfonamide-type drugs. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swellings of the eyelids or around the eyes. If these effects occur, get emergency help at once. Do not try to drive yourself. Call an ambulance, lie down, cover yourself to keep warm, and prop your feet higher than your head. Stay in that position until help arrives.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Get emergency help immediately if any of the following symptoms of overdose occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Bextra side effects (in more detail)
The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.
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Tarivid Otic Solution may be available in the countries listed below.
Ofloxacin is reported as an ingredient of Tarivid Otic Solution in the following countries:
International Drug Name Search
Resinsodio may be available in the countries listed below.
Polystyrene Sulfonic Acid sodium salt (a derivative of Polystyrene Sulfonic Acid) is reported as an ingredient of Resinsodio in the following countries:
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Ectomin may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Cypermethrin is reported as an ingredient of Ectomin in the following countries:
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Lagotran may be available in the countries listed below.
Lamotrigine is reported as an ingredient of Lagotran in the following countries:
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Vancomycin Enterocaps may be available in the countries listed below.
Vancomycin hydrochloride (a derivative of Vancomycin) is reported as an ingredient of Vancomycin Enterocaps in the following countries:
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Dolidon may be available in the countries listed below.
Caffeine monohydrate (a derivative of Caffeine) is reported as an ingredient of Dolidon in the following countries:
Paracetamol is reported as an ingredient of Dolidon in the following countries:
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Zoom-D may be available in the countries listed below.
Domperidone is reported as an ingredient of Zoom-D in the following countries:
Omeprazole is reported as an ingredient of Zoom-D in the following countries:
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Doxycycline IPS may be available in the countries listed below.
Doxycycline monohydrate (a derivative of Doxycycline) is reported as an ingredient of Doxycycline IPS in the following countries:
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Spirola may be available in the countries listed below.
Spironolactone is reported as an ingredient of Spirola in the following countries:
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Lescol Prolib may be available in the countries listed below.
Fluvastatin sodium salt (a derivative of Fluvastatin) is reported as an ingredient of Lescol Prolib in the following countries:
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In some countries, this medicine may only be approved for veterinary use.
Milbemycin Oxime is reported as an ingredient of SaveHeart in the following countries:
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Ciella may be available in the countries listed below.
Salicylic Acid is reported as an ingredient of Ciella in the following countries:
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Ronistina may be available in the countries listed below.
Betahistine dihydrochloride (a derivative of Betahistine) is reported as an ingredient of Ronistina in the following countries:
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Sodium (polystyrène sulfonate de) may be available in the countries listed below.
Sodium (polystyrène sulfonate de) (DCF) is also known as Polystyrene Sulfonic Acid
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Glossary
| DCF | Dénomination Commune Française |
Rec.INN
N06BX11
0072432-10-1
C12-H13-N-O3
219
Nootropic
2-Pyrrolidinone, 1-(4-methoxybenzoyl)-
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Glossary
| IS | Inofficial Synonym |
| JAN | Japanese Accepted Name |
| OS | Official Synonym |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
| USAN | United States Adopted Name |
Procaina Larjan may be available in the countries listed below.
Procaine hydrochloride (a derivative of Procaine) is reported as an ingredient of Procaina Larjan in the following countries:
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Betaglid may be available in the countries listed below.
Glimepiride is reported as an ingredient of Betaglid in the following countries:
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DivistaTM is specially designed as a once a day nutritional adjuvant to the current standard of care for patients with, or at risk of developing type 2 diabetes mellitus (T2DM). DivistaTM provides a method for reducing hyperglycemia and stabilizing the level of serum cholesterol.
DivistaTM is unique in that it utilizes two patented nutritional ingredients, Chromax® (chromium picolinate) and Diachrome® (chromium picolinate and biotin), along with Omega-3 fatty acids to aid in enhancing insulin sensitivity and improve blood sugar metabolism, while promoting healthy lipids and supporting healthy triglyceride levels.
Chromium: is an essential trace mineral required by the human body for normal carbohydrate and lipid metabolism (Wilson and Gondy, 1995). A number of diabetes-like signs and symptoms are seen in chromium deficiency including impaired glucose tolerance, fasting hyperglycemia, glucosuria, elevated circulating insulin and peripheral neuropathy. Dietary chromium intake less than 25% has been reported to adversely affect insulin sensitivity in subjects with mildly impaired glucose tolerance (Anderson, 2000). Over time, urinary chromium losses may contribute to insulin resistance and exacerbate compromised insulin sensitivity in individuals with type 2 diabetes mellitus (T2DM). (Anderson et al., 1991 ; Cefalu and Hu, 2004)
It has been reported that chromium complexes bind to an oligopeptide in order to become biologically active (Davis 1997). The chromium-bound peptide then binds to the insulin receptor and activates tyrosine kinase, amplifying insulin action (Cefalu and Hu, 2004; Wang et al., 2006). In vivo studies have shown that chromium picolinate stimulates intracellular GLUT-4 transporters to translocate from intracellular to the plasma membrane leading to enhanced glucose uptake in muscle cells. (Cefalu et al., 2002, Cefalu and Hu, 2004)
Daily Adequate Intake (AI) of chromium as set by the Institute of Medicine (IOM) is 35 μg for men and 25 μg for women (Food and Nutrition Board (FNB), 2002). A Daily Value (DV) for chromium in food and supplement labels of 120 μg per day was set in 1997 (Trumbo et al.,2001). Based on current research a Tolerable Upper Limit for chromium has not been established by the IOM.
Biotin: is a water-soluble B-complex vitamin necessary for protein, fat and carbohydrate metabolism. It is associated with the proper endogenous production of necessary fatty acids, lymphocytes, digestive enzymes and tissue metabolism. It feces, whereas absorbed amounts of biotin, which exceed the storage capacity of the organism are eliminated in the urine. Shortly after an oral take up of biotin, the biotin concentration in the plasma increases several times, but after 24 h the average value is reached again. In pharmacological dosages (mg-range), biotin stimulates the differentiation of epidermal cells. The effect is independent from the biotin status and influences all keratin structures, like hair, skin and nails.
Recent studies have shown that the elderly with 300 ng/l have a lower biotin level than younger adults and children, whose optimal range lies between 400 and 500 ng/l (Helbich Endermann et al., 1999). The biotin concentration in urine of all age groups is approximately 30 to 40 times higher than the respective serum concentration.
Chromium: Metabolism: The biologically active trivalent state of chromium (Cr3+) is responsible for its nutritional activity. The principal route by which trivalent chromium enters the body is the digestive system. Absorbed chromium circulates as free Cr3+, as Cr3+ bound to transferrin or other plasma proteins (Yamamoto et al. 1987, 1988; Vincent, 2000), or as complexes, such as glucose tolerance factor (GTF) (ATSDR 1998, EPA 1998a). Circulating trivalent chromium can be taken up by tissues, and its distribution in the body depends on the species, age, and chemical form.
The GTF may function by facilitating interaction between insulin and its receptor site, but additional investigations will be required to elucidate the exact mechanisms involved in the essentiality of trivalent chromium. The low molecular weight, chromium-binding complex identified from such sources as bovine milk and rabbit liver has been shown to have in vitro activities comparable to those of GTF with respect to insulin action (Yamamoto et al. 1987, 1988). Chromium is excreted primarily in the urine by glomerular filtration or bound to a low mol-wt organic transporter.
Biotin: Metabolism: Within cells, carboxylases are biotinylated via holocarboxylase synthase, requiring ATP and magnesium. Biotin is recycled from carboxylases via the action of proteolytic enzymes and biotinidase. Biotin is catabolized to a number of metabolites, including bisnorbiotin, biotin sulfoxide, biotin sulfone, and others.
Chromium: Elimination: Absorbed chromium is excreted mainly in the urine; small amounts are lost in hair, perspiration and bile. The 24-hour urinary excretion rates for normal human subjects are reported to be 0.22 μg/day (Gargas et al., 1994), consistent with the relatively low-absorption rate (approximately 0.5%) and typical daily chromium consumption rates (62-85 μg/day) (Anderson et al., 1983).
The tissue distribution, urinary and fecal loss and subcellular hepatocyte distribution and concentration of labels suggest that chromium picolinate has a lifetime of less than 1 day in vivo model. (Hepburn et al., 2002) Half life estimations are based on the three compartment model suggest that elimination from compartment one is relatively fast with a reported half life of seven hours. Elimination from compartments two and three are much slower with reported half lifes of fifteen days and three years respectively. (Gargas, 1994)
Biotin: Elimination: Biotin and biotin metabolites such as bisnorbiotin, biotin-d,l-sulfoxide, bisnorbiotin methyl ketone, and biotin sulfone are excreted in the urine.
There are no reported studies regarding the pharmacokinetic parameters of chromium picolinate or biotin in the geriatric population.
There are no reported studies regarding the pharmacokinetic parameters of chromium picolinate or biotin in the pediatric population.
Chromium: It has been noted that concomitant administration of antacids interferes with chromium absorption whereas aspirin and vitamin C administration potentiate absorption (Ref). However, the overall interference and potentiation of chromium absorption in these cases is minimal and not of clinically relevant concern.
Chromium may compete for one of the binding sites on the iron transport protein, transferrin (Lukaski et al., 1996). Serum iron concentrations and serum ferritin concentrations were unchanged by either resistive training or chromium picolinate supplementation. The high-dose chromium picolinate supplementation for 12 wk did not influence hematologic indexes or indexes of iron metabolism (Campbell, 1997).
Administration of 100 mg vitamin C with 1 mg of chromium resulted in higher plasma levels of chromium than with 1 mg of chromium alone (Food and Nutrition Board, 2001).
Diets high in simple sugars (e.g. sucrose), compared to diets high in complex carbohydrates (e.g. whole grains) increase urinary chromium excretion in adults. This effect may be related is a cofactor required of four enzymes that are involved in carboxylation reactions (acetyl-CoA carboxylase, pyruvate carboxylase, methylcrotonyl-CoA carboxylase, and propionyl- CoA carboxylase) (Dakshinamurti and Cheah-Tan 1968, Dakshinamurti et al., 1970) Biotin has been shown to stimulate hepatic glucokinase, increase pancreatic insulin production through glucokinase mRNA expression and enhance glucose uptake in muscle cells (Spence and Koudelka, 1984, Rodriguez et al., 2001, Trumble et al., 1991). It has been reported that biotin may also decrease expression of phosphoenolpryuvate carboxykinase, an enzyme necessary to down regulate hepatic gluconeogenisis (Dakshinamurti and Li, 1994). In animal and human clinical studies, biotin has been shown to enhance glucokinase activity and lower blood glucose (Romero-Navaro et al., 1999, Furukawa, 1999). Biotin appears to potentiate glucose-induced insulin release but does not appear to directly affect insulin release (Yoshikawa et al., 2002). /Symptoms of overt biotin deficiency include hair loss and a scaly red rash around the eyes, nose, mouth, and genital area. Neurological symptoms in adults have included depression, lethargy, hallucination, and numbness and tingling of the extremities. Individuals with hereditary disorders of biotin metabolism resulting in functional biotin deficiency have evidence of impaired immune system function, including increased susceptibility to bacterial and fungal infections. Zhang et al. (1997) reported low blood biotin levels in 43 non-insulin dependent diabetes mellitus patients with impaired utilization of glucose.
The AI for biotin assumes that current average intakes of biotin (35 mcg to 60 mcg/day) are meeting the dietary requirement (FNB-IOM, 1998). The IOM currently recommends an AI level for biotin of 35-60 μg/day for adults. (Food and Nutrition Board, 2000). The Daily Value (DV) for biotin in food and supplement labels is 300 μg per day. Based on current research a Tolerable Upper Limit for biotin has not been established by the IOM.
Folic Acid: Folic Acid is one of the important hematopoetic agents necessary for proper regeneration of the blood-forming elements and their function. Folic acid is a precursor of a large family of compounds which serve as coenzymes in carbon transfer reactions.
These reactions are required for the synthesis of purine and pyrimidine bases, interconversion of glycine and serine, biosynthesis of methionine methyl groups and degradation of histidine. Additionally, folic acid increases jejunal glycolytic enzymes and is involved in the desaturation and hydroxylation of long-chain fatty acids in the brain. A deficiency in folic acid results in megaloblastic anemia.
DivistaTM (Diachrome® (Chromax® chromium picolinate), Biotin, B6, B12, Folic Acid, Omega-3 Fatty Acids) is a prescription preparation indicated in the adjunctive treatment in patients at risk of developing type 2 diabetes mellitus (T2DM). DivistaTM regulates blood glucose levels, improves insulin sensitivity, and reduces hyperglycemia. DivistaTM is also designed to stabilize serum cholesterol levels to promote cardiovascular health. Optimal results have been observed after 90 days of administration, however improvements may be seen as soon as 30 days. Results will vary depending of the level of glycemic control of the patient at the start of the regimen.
DivistaTM is contraindicated in individuals who are hypersensitive or allergic to any active or inactive ingredients contained in the product including fish or fish oil.
Warning: Ingestion of more than 3 grams of omega-3 fatty acids from fish oils per day may have potential antithrombotic effects, including an increased in bleeding time and INR (international normalized ratio). DHA should be avoided in patients with inherited or acquired bleeding diathesis, including those taking anticoagulants.
Warning: Folic acid alone is improper therapy in the treatment for pernicious anemia and other megaloblastic anemias where Vitamin B12 is deficient.
General: Folic acid in doses above 0.1 mg - 0.4 mg daily may obscure pernicious anemia, in that hematological remission can occur while neurological manifestations remain progressive.
There have been no additional or confirmational reports, nor have there been any substantiated serious adverse events reported by subjects participating in chromium picolinate clinical studies considered related to the product.
As with all nutritional supplements, pregnant or lactating women or individuals with serious health conditions should consult a physician.
Carcinogenesis, mutagenesis, impairment of fertility: Neither chromium picolinatenor biotin has been shown to be mutagenic or carcinogenic in vivo.
Folic acid: Allergic sensitizations have been reported following both oral and parenteral administration of folic acid.
The oral reference dose (RFD) for chromium, the upper limit of exposure thought to protect high risk populations including infants and pregnant women from toxicity, is 70,000 μg/ day. (Maher, 1999)
Adults (persons over 12 years of age), one (1) softgel daily, orally, or as prescribed by a physician. Do not exceed recommended dosage. Do not administer to children under the age of 12.
DivistaTM are opaque blue gelatin softgels imprinted “Divista 110”. Child resistant bottles of 60 softgel capsules. NDC# 52747-110-60. Dispense in a tight, light resistant container as defined by in the USP/NF. Store at room temperature 15° to 30°C (59° to 86° F). Keep in cool, dry place. Softgels are not USP.
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| Marketing Information | |||
| Marketing Category | Application Number or Monograph Citation | Marketing Start Date | Marketing End Date |
| unapproved drug other | 07/10/2010 | ||
| Labeler - US Pharmaceutical Corporation (048318224) |
| Registrant - US Pharmaceutical Corporation (048318224) |
Exylin may be available in the countries listed below.
Diphenhydramine hydrochloride (a derivative of Diphenhydramine) is reported as an ingredient of Exylin in the following countries:
International Drug Name Search
Cesflan may be available in the countries listed below.
Pranoprofen is reported as an ingredient of Cesflan in the following countries:
International Drug Name Search
Altocel may be available in the countries listed below.
Loperamide hydrochloride (a derivative of Loperamide) is reported as an ingredient of Altocel in the following countries:
International Drug Name Search
Urokinase Vedim may be available in the countries listed below.
Urokinase is reported as an ingredient of Urokinase Vedim in the following countries:
International Drug Name Search
Tatsujipin may be available in the countries listed below.
Benazepril hydrochloride (a derivative of Benazepril) is reported as an ingredient of Tatsujipin in the following countries:
International Drug Name Search
Bisoprolol HCT AWD may be available in the countries listed below.
Bisoprolol fumarate (a derivative of Bisoprolol) is reported as an ingredient of Bisoprolol HCT AWD in the following countries:
Hydrochlorothiazide is reported as an ingredient of Bisoprolol HCT AWD in the following countries:
International Drug Name Search
Contol may be available in the countries listed below.
Chlordiazepoxide is reported as an ingredient of Contol in the following countries:
International Drug Name Search
Diclomax may be available in the countries listed below.
UK matches:
Diclofenac sodium salt (a derivative of Diclofenac) is reported as an ingredient of Diclomax in the following countries:
Dicloxacillin sodium salt (a derivative of Dicloxacillin) is reported as an ingredient of Diclomax in the following countries:
International Drug Name Search
Glossary
| SPC | Summary of Product Characteristics (UK) |
Acetaminofén may be available in the countries listed below.
Paracetamol is reported as an ingredient of Acetaminofén in the following countries:
International Drug Name Search
Cyclacillin may be available in the countries listed below.
Cyclacillin (USAN) is also known as Ciclacillin (Rec.INN)
International Drug Name Search
Glossary
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
| USAN | United States Adopted Name |
Rantin may be available in the countries listed below.
Ranitidine hydrochloride (a derivative of Ranitidine) is reported as an ingredient of Rantin in the following countries:
International Drug Name Search
Sunatrim may be available in the countries listed below.
Sulfamethoxazole is reported as an ingredient of Sunatrim in the following countries:
Trimethoprim is reported as an ingredient of Sunatrim in the following countries:
International Drug Name Search
Felsol may be available in the countries listed below.
Fluconazole is reported as an ingredient of Felsol in the following countries:
International Drug Name Search
Estradiol Benzoate may be available in the countries listed below.
Estradiol Benzoate (BANM, JAN) is known as Estradiol in the US.
International Drug Name Search
Glossary
| BANM | British Approved Name (Modified) |
| JAN | Japanese Accepted Name |
Spironolactonã may be available in the countries listed below.
Spironolactone is reported as an ingredient of Spironolactonã in the following countries:
International Drug Name Search
Ceftazidima Actavis may be available in the countries listed below.
Ceftazidime pentahydrate (a derivative of Ceftazidime) is reported as an ingredient of Ceftazidima Actavis in the following countries:
International Drug Name Search
Carbocaine is a brand name of mepivacaine, approved by the FDA in the following formulation(s):
Yes. The following products are equivalent to Carbocaine:
Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Carbocaine. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.
See also: About generic drugs.
There are no current U.S. patents associated with Carbocaine.
Carbon Eczane may be available in the countries listed below.
Charcoal, Activated is reported as an ingredient of Carbon Eczane in the following countries:
International Drug Name Search
Gravi-Fol may be available in the countries listed below.
Folic Acid is reported as an ingredient of Gravi-Fol in the following countries:
International Drug Name Search
Inalacor Accuhaler may be available in the countries listed below.
Fluticasone propionate (a derivative of Fluticasone) is reported as an ingredient of Inalacor Accuhaler in the following countries:
International Drug Name Search
Vitasol A-D3-E may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Colecalciferol is reported as an ingredient of Vitasol A-D3-E in the following countries:
Retinol palmitate (a derivative of Retinol) is reported as an ingredient of Vitasol A-D3-E in the following countries:
Tocopherol, α- acetate (a derivative of Tocopherol, α-) is reported as an ingredient of Vitasol A-D3-E in the following countries:
International Drug Name Search
Cefalexina Lafedar may be available in the countries listed below.
Cefalexin monohydrate (a derivative of Cefalexin) is reported as an ingredient of Cefalexina Lafedar in the following countries:
International Drug Name Search
Hestar may be available in the countries listed below.
Hetastarch is reported as an ingredient of Hestar in the following countries:
Pentalamide is reported as an ingredient of Hestar in the following countries:
International Drug Name Search
Curoxime may be available in the countries listed below.
Cefuroxime sodium salt (a derivative of Cefuroxime) is reported as an ingredient of Curoxime in the following countries:
International Drug Name Search
Mirtazapine Qualimed may be available in the countries listed below.
Mirtazapine is reported as an ingredient of Mirtazapine Qualimed in the following countries:
International Drug Name Search